Treatment of carbon tetrachloride fatty liver with diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105)
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منابع مشابه
Effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on drug metabolizing activity in rat liver microsomes.
The effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on drug metabolizing activity in rat liver microsomes was examined. Malotilate (500 mg/kg/day) was administered orally to rats for 3 days. The contents of cytochrome P-450 (P-450) and cytochrome b5 (b5), the activity of NADPH-cytochrome c reductase, and the metabolization of aniline, aminopyrine, benzo(a)pyrene (B(a)P) and 7-e...
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After the administration of ccl4 to male rats, liver triglycerides began to increase after a lag period of about 1 hr; the level of serum triglycerides fell sharply during the first 30 min of intoxication. Three classes of serum lipoproteins were isolated by flotation in the ultracentrifuge and their concentrations and chemical compositions were determined. Within 4 hr of the administration of ...
متن کاملPreventive effect of malotilate on carbon tetrachloride-induced liver damage and collagen accumulation in the rat.
Malotilate is a new drug suggested for use in chronic liver diseases. It is shown here to prevent liver damage caused by CCl4. The concomitant administration of malotilate with CCl4 significantly decreased hydroxyproline accumulation in the liver, liver prolyl 4-hydroxylase and liver and serum galactosylhydroxylysyl glucosyltransferase activities. However, it had no effect on the daily urinary ...
متن کاملAnti-alcohol action of hepaticoactivator (NKK-105) on motoricity and EEG in experimental animals and man.
The effects of a hepaticoactivator, diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105), on motoricity and EEG were observed int he rat, mouse, cat and man. NKK-105 suppressed the effects of ethanol (1,000-3,000 mg/kg, p.o., in mice and rats), e.g. the blood alcohol concentration of NKK-105 treated subjects was significantly lower than that of untreated controls. NKK-105, in 100-300 mg/kg p.o...
متن کاملBiochemical changes in carbon tetrachloride fatty liver: separation of fatty changes from mitochondrial degeneration.
In 1954 Christie and Judah (3) in a study of the mechanism of action of carbon tetrachloride advanced the view that the primary locus of action of this hepatotoxin was the membranes of the liver mitochondria. Dianzani (4-6) showed that after carbon tetrachloride or phosphorus poisoning or after a choline deficient diet, there was evidence for uncoupling of oxidative phosphorylation, loss of mit...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1978
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)67228-8